Jun 092012
 
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Lets have a look at the link between Leaky gut syndrome and Vitamin D.

Increased intestinal permeability (leaky gut) is a common condition among Inflammatory bowel disease (IBD) sufferers. This study „Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier“ looked at the link at the link between inflammatory bowel disease and vitamin D and found that the leaky gut healing is impaired in the absence of Vitamin D:

“In summary, in this report we presented evidence suggesting that the VDR (Vitamin D Receptor) plays a critical role in preserving the integrity of the intestinal mucosal barrier. VDR is able to enhance the intercellular junctions; it is also required for mucosal wound healing.”

“vitamin D deficiency is linked to increased incidence of IBD in human population”

“vitamin D deficiency may compromise the mucosal barrier, leading to increased susceptibility to mucosal damage and increased risk of IBD”

“vitamin D deficiency or vitamin D receptor (VDR) deficiency exacerbates the symptoms of enterocolitis and increases morbidity and mortality due to increased T cell-mediated immune response in the intestine “

This study Children born in the summer have increased risk for coeliac disease  studied 2000 swedish children with coeliac disease and found significantly increased likelihood of coeliac disease in children under age of 2 for those born in the summer.

Possible mechanism could be that the vitamin D deficiency during the winter caused leaky gut that coincided with the introduction to gluten containing foods at 6  months of age.

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